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Targeting the Tie2–α(v)β(3) integrin axis with bi-specific reagents for the inhibition of angiogenesis
BACKGROUND: Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2, rendering the Ang/Tie2/integrin axis an attractive...
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| Publié dans: | BMC Biol |
|---|---|
| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097439/ https://ncbi.nlm.nih.gov/pubmed/30119679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0557-9 |
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