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Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy

In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant impact on cancer therapy. Nevertheless, attempts...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Shlamkovich, Tomer, Aharon, Lidan, Barton, William A., Papo, Niv
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464891/
https://ncbi.nlm.nih.gov/pubmed/28422724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16827
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