Targeting the Tie2–α(v)β(3) integrin axis with bi-specific reagents for the inhibition of angiogenesis

BACKGROUND: Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2, rendering the Ang/Tie2/integrin axis an attractive...

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Vydáno v:BMC Biol
Hlavní autoři: Shlamkovich, Tomer, Aharon, Lidan, Koslawsky, Dana, Einav, Yulia, Papo, Niv
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6097439/
https://ncbi.nlm.nih.gov/pubmed/30119679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0557-9
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