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Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy
Crosstalk of the oncogenic matrix metalloproteinase-9 (MMP9) and one of its ligands, CD44, involves cleavage of CD44 by the MMP9 catalytic domain, with the CD44–MMP9 interaction on the cell surface taking place through the MMP9 hemopexin domain (PEX). This interaction promotes cancer cell migration...
Gorde:
| Argitaratua izan da: | Biochem J |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Portland Press Ltd.
2021
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7959692/ https://ncbi.nlm.nih.gov/pubmed/33600567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200628 |
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