Inhibition of MMP-9-dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4

Degradation and remodeling of the extracellular matrix by matrix metalloproteinases (MMPs) plays important roles in normal development, inflammation, and cancer. MMP-9 efficiently degrades the extracellular matrix component gelatin, and the hemopexin domain of MMP-9 (PEX9) inhibits this degradation....

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ugarte-Berzal, Estefanía, Vandooren, Jennifer, Bailón, Elvira, Opdenakker, Ghislain, García-Pardo, Angeles
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882443/
https://ncbi.nlm.nih.gov/pubmed/27044750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.708438
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