Identification of Function for CD44 Intracytoplasmic Domain (CD44-ICD): MODULATION OF MATRIX METALLOPROTEINASE 9 (MMP-9) TRANSCRIPTION VIA NOVEL PROMOTER RESPONSE ELEMENT

CD44 is a multifunctional cell receptor that conveys a cancer phenotype, regulates macrophage inflammatory gene expression and vascular gene activation in proatherogenic environments, and is also a marker of many cancer stem cells. CD44 undergoes sequential proteolytic cleavages that produce an intr...

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Detalhes bibliográficos
Main Authors: Miletti-González, Karl E., Murphy, Kyle, Kumaran, Muthu N., Ravindranath, Abhilash K., Wernyj, Roman P., Kaur, Swayamjot, Miles, Gregory D., Lim, Elaine, Chan, Rigel, Chekmareva, Marina, Heller, Debra S., Foran, David, Chen, Wenjin, Reiss, Michael, Bandera, Elisa V., Scotto, Kathleen, Rodríguez-Rodríguez, Lorna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365933/
https://ncbi.nlm.nih.gov/pubmed/22433859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.318774
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