Small Molecule Anti-Cancer Compounds Selectively Target the Hemopexin Domain of Matrix Metalloproteinase-9 (MMP-9)

Lack of target specificity by existing matrix metalloproteinase (MMP) inhibitors has hindered anti-metastatic cancer drug discovery. Inhibitors that bind to non-catalytic sites of MMPs and disrupt protease signaling function have the potential to be more specific and selective. In this work, compoun...

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Bibliographic Details
Main Authors: Dufour, Antoine, Sampson, Nicole S., Li, Jian, Kuscu, Cem, Rizzo, Robert C., DeLeon, Jennifer L., Zhi, Jizu, Jaber, Nadia, Liu, Eric, Zucker, Stanley, Cao, Jian
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138841/
https://ncbi.nlm.nih.gov/pubmed/21646471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-4552
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