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Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement

Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood. We now have demonstrated that furin serves as an intermolecular chaperone for MMP-28 secretion by interacting with the propeptide doma...

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Autors principals: Pavlaki, Maria, Zucker, Stanley, Dufour, Antoine, Calabrese, Nikki, Bahou, Wadie, Cao, Jian
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989691/
https://ncbi.nlm.nih.gov/pubmed/21152186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/630319
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