Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement

Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood. We now have demonstrated that furin serves as an intermolecular chaperone for MMP-28 secretion by interacting with the propeptide doma...

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Hauptverfasser: Pavlaki, Maria, Zucker, Stanley, Dufour, Antoine, Calabrese, Nikki, Bahou, Wadie, Cao, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989691/
https://ncbi.nlm.nih.gov/pubmed/21152186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/630319
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