Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement

Although MMP-28 is involved in numerous important physiologic and pathologic conditions, the mechanisms of action of this secreted proteinase is not well understood. We now have demonstrated that furin serves as an intermolecular chaperone for MMP-28 secretion by interacting with the propeptide doma...

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Main Authors: Pavlaki, Maria, Zucker, Stanley, Dufour, Antoine, Calabrese, Nikki, Bahou, Wadie, Cao, Jian
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2989691/
https://ncbi.nlm.nih.gov/pubmed/21152186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/630319
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