Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Degradation of the extracellular matrices in the human body is controlled by matrix metalloproteinases (MMPs), a family of more than 20 homologous enzymes. Imbalance in MMP activity can result in many diseases, such as arthritis, cardiovascular diseases, neurological disorders, fibrosis, and cancers...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Arkadash, Valeria, Yosef, Gal, Shirian, Jason, Cohen, Itay, Horev, Yuval, Grossman, Moran, Sagi, Irit, Radisky, Evette S., Shifman, Julia M., Papo, Niv
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Enzymology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5336179/
https://ncbi.nlm.nih.gov/pubmed/28087697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.756718
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