Tradeoff Between Stability and Multispecificity in the Design of Promiscuous Proteins

Por Fromer, Menachem, Shifman, Julia M.
Publicado em 2009

Exploring the origins of binding specificity through the computational redesign of calmodulin

Por Shifman, Julia M., Mayo, Stephen L.
Publicado em 2003

How Structure Defines Affinity in Protein-Protein Interactions

Por Erijman, Ariel, Rosenthal, Eran, Shifman, Julia M.
Publicado em 2014

Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21

Por Leung, Isabel, Dekel, Ayelet, Shifman, Julia M., Sidhu, Sachdev S.
Publicado no Proc Natl Acad Sci U S A (2016)

Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs

Por Sharabi, Oz, Shirian, Jason, Grossman, Moran, Lebendiker, Mario, Sagi, Irit, Shifman, Julia
Publicado em 2014

Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS

Por Rosenfeld, Lior, Shirian, Jason, Zur, Yuval, Levaot, Noam, Shifman, Julia M., Papo, Niv
Publicado no J Biol Chem (2015)

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums

Por Shifman, Julia M., Choi, Mee H., Mihalas, Stefan, Mayo, Stephen L., Kennedy, Mary B.
Publicado em 2006

Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase

Por Sharabi, Oz, Peleg, Yoav, Mashiach, Efrat, Vardy, Eyal, Ashani, Yacov, Silman, Israel, Sussman, Joel L., Shifman, Julia M.
Publicado em 2009

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution

Por Arkadash, Valeria, Yosef, Gal, Shirian, Jason, Cohen, Itay, Horev, Yuval, Grossman, Moran, Sagi, Irit, Radisky, Evette S., Shifman, Julia M., Papo, Niv
Publicado no J Biol Chem (2017)