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Exploring the origins of binding specificity through the computational redesign of calmodulin
Calmodulin (CaM) is a second messenger protein that has evolved to bind tightly to a variety of targets and, as such, exhibits low binding specificity. We redesigned CaM by using a computational protein design algorithm to improve its binding specificity for one of its targets, smooth muscle myosin...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC263780/ https://ncbi.nlm.nih.gov/pubmed/14597710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2234277100 |
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