Proximal Tubule–Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis

BACKGROUND: Sustained activation of EGF receptor (EGFR) in proximal tubule cells is a hallmark of progressive kidney fibrosis after AKI and in CKD. However, the molecular mechanisms and particular EGFR ligands involved are unknown. METHODS: We studied EGFR activation in proximal tubule cells and pri...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Kefaloyianni, Eirini, Keerthi Raja, Manikanda Raja, Schumacher, Julian, Muthu, Muthu Lakshmi, Krishnadoss, Vaishali, Waikar, Sushrut S., Herrlich, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2019
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6900800/
https://ncbi.nlm.nih.gov/pubmed/31676723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019030321
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