ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterized from Escherichia coli, is a competitive inhibitor...

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Détails bibliographiques
Auteurs principaux: Moss, Marcia L., Powell, Gary, Miller, Miles A., Edwards, Lori, Qi, Bin, Sang, Qing-Xiang Amy, De Strooper, Bart, Tesseur, Ina, Lichtenthaler, Stefan F., Taverna, Mara, Zhong, Julia Li, Dingwall, Colin, Ferdous, Taheera, Schlomann, Uwe, Zhou, Pei, Griffith, Linda G., Lauffenburger, Douglas A., Petrovich, Robert, Bartsch, Jörg W.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Enzymology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220463/
https://ncbi.nlm.nih.gov/pubmed/21956108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280495
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