ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), expressed and characterized from Escherichia coli, is a competitive inhibitor...

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書誌詳細
主要な著者: Moss, Marcia L., Powell, Gary, Miller, Miles A., Edwards, Lori, Qi, Bin, Sang, Qing-Xiang Amy, De Strooper, Bart, Tesseur, Ina, Lichtenthaler, Stefan F., Taverna, Mara, Zhong, Julia Li, Dingwall, Colin, Ferdous, Taheera, Schlomann, Uwe, Zhou, Pei, Griffith, Linda G., Lauffenburger, Douglas A., Petrovich, Robert, Bartsch, Jörg W.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
Enzymology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220463/
https://ncbi.nlm.nih.gov/pubmed/21956108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.280495
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