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Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

Mammalian life span can be extended by both calorie restriction (CR) and mutations that diminish somatotropic signaling. Sirt1 is a mediator of many effects of CR in mammals, but any role in controlling somatotropic signaling has not been shown. Since the somatotropic axis is controlled by the brain...

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Библиографические подробности
Главные авторы: Cohen, Dena E., Supinski, Andrea M., Bonkowski, Michael S., Donmez, Gizem, Guarente, Leonard P.
Формат: Artigo
Язык:Inglês
Опубликовано: Cold Spring Harbor Laboratory Press 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800085/
https://ncbi.nlm.nih.gov/pubmed/20008932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1839209
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