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DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION
Suppressed neuroendocrine signaling is a common trait in many long-lived mouse mutants and mice on calorie restriction. Loss-of-function mutations in the pituitary Pit1 and Prop1 genes in Snell and Ames dwarf mice were the first mutations known to extend lifespan in mammals. Evidence indicates that...
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| Publicado no: | Innov Aging |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6229477/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/geroni/igy023.337 |
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