The role of calorie restriction and SIRT1 in prion mediated neurodegeneration

A central focus of aging research is to determine how calorie restriction (CR) extends lifespan and delays diseases of aging. SIRT1, the mammalian ortholog of Sir2 in yeast, is a longevity factor which mediates dietary restriction in diverse species. In addition, SIRT1 plays a protective role in sev...

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Detalhes bibliográficos
Main Authors: Chen, Danica, Steele, Andrew D., Hutter, Gregor, Bruno, Joanne, Govindarajan, Arvind, Easlon, Erin, Lin, Su-Ju, Aguzzi, Adriano, Lindquist, Susan, Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735260/
https://ncbi.nlm.nih.gov/pubmed/18799131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2008.08.050
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