ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity called α-secretase. This is considered an important mechanism preventing the generation of the Alzheimer's disease amyloid-β peptide (Aβ). α-Secretase appears to be a metalloprotease of the ADAM family, b...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kuhn, Peer-Hendrik, Wang, Huanhuan, Dislich, Bastian, Colombo, Alessio, Zeitschel, Ulrike, Ellwart, Joachim W, Kremmer, Elisabeth, Roßner, Steffen, Lichtenthaler, Stefan F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944055/
https://ncbi.nlm.nih.gov/pubmed/20676056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.167
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados