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ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity called α-secretase. This is considered an important mechanism preventing the generation of the Alzheimer's disease amyloid-β peptide (Aβ). α-Secretase appears to be a metalloprotease of the ADAM family, b...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2944055/ https://ncbi.nlm.nih.gov/pubmed/20676056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.167 |
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