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Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Proteolytic cleavage of the amyloid precursor protein (APP) by the two proteases α- and β-secretases controls the generation of the amyloid β peptide (Aβ), a key player in Alzheimer’s disease pathogenesis. The α-secretase ADAM10 and the β-secretase BACE1 have opposite effects on Aβ generation and ar...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Neurobiol Dis
Main Authors: Colombo, Alessio, Wang, Huanhuan, Kuhn, Peer-Hendrik, Page, Richard, Kremmer, Elisabeth, Dempsey, Peter J., Crawford, Howard C., Lichtenthaler, Stefan F.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4310234/
https://ncbi.nlm.nih.gov/pubmed/22940630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.011
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