Nalaganje...
Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
Proteolytic cleavage of the amyloid precursor protein (APP) by the two proteases α- and β-secretases controls the generation of the amyloid β peptide (Aβ), a key player in Alzheimer’s disease pathogenesis. The α-secretase ADAM10 and the β-secretase BACE1 have opposite effects on Aβ generation and ar...
Shranjeno v:
| izdano v: | Neurobiol Dis |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4310234/ https://ncbi.nlm.nih.gov/pubmed/22940630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.011 |
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