Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative α-secretase within the Aβ sequence precludes the formation...

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Detalhes bibliográficos
Main Authors: Lammich, Sven, Kojro, Elzbieta, Postina, Rolf, Gilbert, Sandra, Pfeiffer, Roland, Jasionowski, Marek, Haass, Christian, Fahrenholz, Falk
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22396/
https://ncbi.nlm.nih.gov/pubmed/10097139
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