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Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative α-secretase within the Aβ sequence precludes the formation...

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Bibliografiske detaljer
Main Authors: Lammich, Sven, Kojro, Elzbieta, Postina, Rolf, Gilbert, Sandra, Pfeiffer, Roland, Jasionowski, Marek, Haass, Christian, Fahrenholz, Falk
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22396/
https://ncbi.nlm.nih.gov/pubmed/10097139
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