A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

Alzheimer disease (AD) is characterized by excessive deposition of amyloid β-peptides (Aβ peptides) in the brain. In the nonamyloidogenic pathway, the amyloid precursor protein (APP) is cleaved by the α-secretase within the Aβ peptide sequence. Proteinases of the ADAM family (a disintegrin and metal...

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Publicado en:J Clin Invest
Main Authors: Postina, Rolf, Schroeder, Anja, Dewachter, Ilse, Bohl, Juergen, Schmitt, Ulrich, Kojro, Elzbieta, Prinzen, Claudia, Endres, Kristina, Hiemke, Christoph, Blessing, Manfred, Flamez, Pascaline, Dequenne, Antoine, Godaux, Emile, van Leuven, Fred, Fahrenholz, Falk
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC406531/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15146243/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20864
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