Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Proteolytic cleavage of the amyloid precursor protein (APP) by the two proteases α- and β-secretases controls the generation of the amyloid β peptide (Aβ), a key player in Alzheimer's disease pathogenesis. The α-secretase ADAM10 and the β-secretase BACE1 have opposite effects on Aβ generation and ar...

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Bibliografiske detaljer

Principais autores:	Alessio Colombo, Huanhuan Wang, Peer-Hendrik Kuhn, Richard Page, Elisabeth Kremmer, Peter J. Dempsey, Howard C. Crawford, Stefan F. Lichtenthaler
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2013-01-01
Serier:	Neurobiology of Disease
Fag:	Alzheimer's disease Alpha-secretase Beta-secretase Amyloid precursor protein
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0969996112002987
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