γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).

The relative increase in Aβ42 peptides from familial Alzheimer disease (FAD) linked APP and PSEN mutations can be related to changes in both ε-cleavage site utilization and subsequent step-wise cleavage. Cleavage at the ε-site releases the amyloid precursor protein (APP) intracellular domain (AICD),...

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Bibliografiske detaljer

Principais autores:	Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2015-01-01
Serier:	PLoS ONE
Online adgang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144758&type=printable
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