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Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Proteolytic processing of the amyloid precursor protein by β-secretase yields A4CT (C99), which is cleaved further by the as yet unknown γ-secretase, yielding the β-amyloid (Aβ) peptide with 40 (Aβ(40)) or 42 residues (Aβ(42)). Because the position of γ-secretase cleavage is crucial for the pathogen...

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Autori principali: Lichtenthaler, Stefan F., Wang, Rong, Grimm, Heike, Uljon, Sacha N., Masters, Colin L., Beyreuther, Konrad
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC15893/
https://ncbi.nlm.nih.gov/pubmed/10077635
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