Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

Proteolytic processing of the amyloid precursor protein by β-secretase yields A4CT (C99), which is cleaved further by the as yet unknown γ-secretase, yielding the β-amyloid (Aβ) peptide with 40 (Aβ(40)) or 42 residues (Aβ(42)). Because the position of γ-secretase cleavage is crucial for the pathogen...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Lichtenthaler, Stefan F., Wang, Rong, Grimm, Heike, Uljon, Sacha N., Masters, Colin L., Beyreuther, Konrad
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3053
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