SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones

α-Synuclein is a key molecule in the pathogenesis of synucleinopathy including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. Sirtuins are NAD(+)-dependent protein deacetylases that are highly conserved and counter aging in lower organisms. We show that the life sp...

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Detalhes bibliográficos
Main Authors: Donmez, Gizem, Arun, Anirudh, Chung, Chee-Yeun, McLean, Pamela J., Lindquist, Susan, Guarente, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263206/
https://ncbi.nlm.nih.gov/pubmed/22219275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3442-11.2012
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