Familial Alzheimer's Disease Presenilin 1 Mutations Cause Alterations in the Conformation of Presenilin and Interactions with Amyloid Precursor Protein

Presenilin 1 (PS1) is a critical component of the γ-secretase complex, an enzymatic activity that cleaves amyloid β (Aβ) from the amyloid precursor protein (APP). More than 100 mutations spread throughout the PS1 molecule are linked to autosomal dominant familial Alzheimer's disease (FAD). All...

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Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Berezovska, Oksana, Lleo, Alberto, Herl, Lauren D., Frosch, Matthew P., Stern, Edward A., Bacskai, Brian J., Hyman, Bradley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2005
Schlagworte:
Neurobiology of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725136/
https://ncbi.nlm.nih.gov/pubmed/15772361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0364-05.2005
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