Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase

Alzheimer's disease is characterized by accumulation of toxic β-amyloid (Aβ) in the brain and neuronal death. Several mutations in presenilin (PS1) and β-amyloid precursor protein (APP) associate with an increased Aβ(42/40) ratio. Aβ(42), a highly fibrillogenic species, is believed to drive Aβ...

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Bibliographic Details
Main Authors: Herl, Lauren, Thomas, Anne V., Lill, Christina M., Banks, Mary, Deng, Amy, Jones, Phill B., Spoelgen, Robert, Hyman, Bradley T., Berezovska, Oksana
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732195/
https://ncbi.nlm.nih.gov/pubmed/19281847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2009.02.008
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