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Mutations in amyloid precursor protein affect its interactions with presenilin/γ-secretase
Alzheimer's disease is characterized by accumulation of toxic β-amyloid (Aβ) in the brain and neuronal death. Several mutations in presenilin (PS1) and β-amyloid precursor protein (APP) associate with an increased Aβ(42/40) ratio. Aβ(42), a highly fibrillogenic species, is believed to drive Aβ...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732195/ https://ncbi.nlm.nih.gov/pubmed/19281847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2009.02.008 |
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