Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging

γ-Secretase cleavage is the final enzymatic step generating β-amyloid via intramembranous cleavage of the amyloid precursor protein (APP). Presenilin (PS), initially identified as a gene in which mutations account for the vast majority of early-onset autosomal dominant Alzheimer's disease, is a...

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Vydáno v:J Neurosci
Hlavní autoři: Berezovska, Oksana, Ramdya, Pavan, Skoch, Jesse, Wolfe, Michael S., Bacskai, Brian J., Hyman, Bradley T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2003
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740808/
https://ncbi.nlm.nih.gov/pubmed/12805296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-11-04560.2003
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