Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging

γ-Secretase cleavage is the final enzymatic step generating β-amyloid via intramembranous cleavage of the amyloid precursor protein (APP). Presenilin (PS), initially identified as a gene in which mutations account for the vast majority of early-onset autosomal dominant Alzheimer's disease, is a...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Berezovska, Oksana, Ramdya, Pavan, Skoch, Jesse, Wolfe, Michael S., Bacskai, Brian J., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740808/
https://ncbi.nlm.nih.gov/pubmed/12805296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-11-04560.2003
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