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Amyloid Precursor Protein Associates with a Nicastrin-Dependent Docking Site on the Presenilin 1–γ-Secretase Complex in Cells Demonstrated by Fluorescence Lifetime Imaging
γ-Secretase cleavage is the final enzymatic step generating β-amyloid via intramembranous cleavage of the amyloid precursor protein (APP). Presenilin (PS), initially identified as a gene in which mutations account for the vast majority of early-onset autosomal dominant Alzheimer's disease, is a...
Zapisane w:
| Wydane w: | J Neurosci |
|---|---|
| Główni autorzy: | , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Society for Neuroscience
2003
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6740808/ https://ncbi.nlm.nih.gov/pubmed/12805296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-11-04560.2003 |
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