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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
Recent studies indicate that nicastrin (NCT) and presenilins form functional components of a multimeric γ-secretase complex required for the regulated intramembraneous proteolysis of Notch and β-amyloid (Aβ) precursor protein (APP). To determine whether nicastrin is required for proteolytic processi...
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| Publicat a: | J Neurosci |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6742329/ https://ncbi.nlm.nih.gov/pubmed/12716934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-08-03272.2003 |
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