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γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin

γ-Secretase is a multiprotein, intramembrane-cleaving protease with a growing list of protein substrates, including the Notch receptors and the amyloid precursor protein. The four components of γ-secretase complex—presenilin (PS), nicastrin (NCT), Pen2, and Aph1—are all thought to be essential for a...

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Detalhes bibliográficos
Main Authors: Zhao, Guojun, Liu, Zhenyi, Ilagan, Ma. Xenia G., Kopan, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853942/
https://ncbi.nlm.nih.gov/pubmed/20130175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3826-09.2010
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