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Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch
The γ-secretase complex is composed of at least four components: presenilin (PS1 or PS2), nicastrin (NCT), anterior pharynx-defective 1 (Aph-1), and presenilin enhancer 2 (pen-2). In this study, using knockout cell lines, our data demonstrated that knockout of NCT, as well as knockout of Pen-2, comp...
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| 出版年: | J Neurochem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4929055/ https://ncbi.nlm.nih.gov/pubmed/26717550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13518 |
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