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The Notch inhibitor cowanin accelerates nicastrin degradation
Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds, including one new natural product from Garcinia...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5876388/ https://ncbi.nlm.nih.gov/pubmed/29599482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23698-4 |
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