Hes1 inhibitor isolated by target protein oriented natural products isolation (TPO-NAPI) of differentiation activators of neural stem cells

The Hes1 dimer inhibitor, agalloside (2), which can accelerate the differentiation of neural stem cells is described. Six natural products, including one new natural product, which bind to Hes1 were rapidly isolated by a developed “target protein oriented natural products isolation” (TPO-NAPI) metho...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Arai, Midori A., Ishikawa, Naoki, Tanaka, Mitsuha, Uemura, Kenji, Sugimitsu, Noriko, Suganami, Akiko, Tamura, Yutaka, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2016
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963671/
https://ncbi.nlm.nih.gov/pubmed/29899896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03540f
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