Target protein-oriented isolation of Hes1 dimer inhibitors using protein based methods

Natural products isolation using protein based methods is an attractive for obtaining bioactive compounds. To discover neural stem cell (NSC) differentiation activators, we isolated eight inhibitors of Hes1 dimer formation from Psidium guajava using the Hes1-Hes1 interaction fluorescent plate assay...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Arai, Midori A., Morita, Kaori, Kawano, Haruka, Makita, Yuna, Hashimoto, Manami, Suganami, Akiko, Tamura, Yutaka, Sadhu, Samir K., Ahmed, Firoj, Ishibashi, Masami
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6987128/
https://ncbi.nlm.nih.gov/pubmed/31992824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58451-3
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