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Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

詳細記述

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書誌詳細
出版年:Sci Rep
主要な著者: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://ncbi.nlm.nih.gov/pubmed/33824364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86952-2
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