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Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://ncbi.nlm.nih.gov/pubmed/33824364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86952-2
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