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Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://ncbi.nlm.nih.gov/pubmed/33824364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86952-2
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