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Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://ncbi.nlm.nih.gov/pubmed/33824364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86952-2
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