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Rational thermostabilisation of four-helix bundle dimeric de novo proteins

The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The stabil...

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Foilsithe in:Sci Rep
Main Authors: Irumagawa, Shin, Kobayashi, Kaito, Saito, Yutaka, Miyata, Takeshi, Umetsu, Mitsuo, Kameda, Tomoshi, Arai, Ryoichi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8024369/
https://ncbi.nlm.nih.gov/pubmed/33824364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-86952-2
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