SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation

Notch receptors and their ligands play important roles in both normal animal development and pathogenesis. We show here that the F-box/WD40 repeat protein SEL-10 negatively regulates Notch receptor activity by targeting the intracellular domain of Notch receptors for ubiquitin-mediated protein degra...

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Autores principales: Wu, Guangyu, Lyapina, Svetlana, Das, Indranil, Li, Jinhe, Gurney, Mark, Pauley, Adele, Chui, Inca, Deshaies, Raymond J., Kitajewski, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC99913/
https://ncbi.nlm.nih.gov/pubmed/11585921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.21.7403-7415.2001
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