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γ-Secretase Composed of PS1/Pen2/Aph1a Can Cleave Notch and Amyloid Precursor Protein in the Absence of Nicastrin
γ-Secretase is a multiprotein, intramembrane-cleaving protease with a growing list of protein substrates, including the Notch receptors and the amyloid precursor protein. The four components of γ-secretase complex—presenilin (PS), nicastrin (NCT), Pen2, and Aph1—are all thought to be essential for a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Society for Neuroscience
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2853942/ https://ncbi.nlm.nih.gov/pubmed/20130175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3826-09.2010 |
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