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PRESENILIN-1 ADOPTS PATHOGENIC CONFORMATION IN NORMAL AGING AND IN SPORADIC ALZHEIMER’S DISEASE

Accumulation of amyloid-β (Aβ) and neurofibrillary tangles in the brain, inflammation and synaptic and neuronal loss are some of the major neuropathological hallmarks of Alzheimer’s disease (AD). While genetic mutations in amyloid precursor protein and presenilin-1 and -2 (PS1 and PS2) genes cause e...

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Bibliografische gegevens
Hoofdauteurs: Wahlster, Lara, Arimon, Muriel, Nasser-Ghodsi, Navine, Post, Kathryn Leigh, Serrano-Pozo, Alberto, Uemura, Kengo, Berezovska, Oksana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552123/
https://ncbi.nlm.nih.gov/pubmed/23138650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-1065-6
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