A carregar...
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
γ-Secretase generates the peptides of Alzheimer's disease, Aβ(40) and Aβ(42), by cleaving the amyloid precursor protein within its transmembrane domain. γ-Secretase also cleaves numerous other substrates, raising concerns about γ-secretase inhibitor off-target effects. Another important class o...
Na minha lista:
| Main Authors: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060602/ https://ncbi.nlm.nih.gov/pubmed/21119643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1129 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|