Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio

BACKGROUND: Presenilin 1(PS1) is the catalytic subunit of γ-secretase, the enzyme responsible for the Aβ C-terminal cleavage site, which results in the production of Aβ peptides of various lengths. Production of longer forms of the Aβ peptide occur in patients with autosomal dominant Alzheimer disea...

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Detalhes bibliográficos
Main Authors: Uemura, Kengo, Lill, Christina M., Li, Xuejing, Peters, Jessica A., Ivanov, Alexander, Fan, Zhanyun, DeStrooper, Bart, Bacskai, Brian J., Hyman, Bradley T., Berezovska, Oksana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773935/
https://ncbi.nlm.nih.gov/pubmed/19924286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007893
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