Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β(42/40) Ratio

BACKGROUND: Presenilin 1(PS1) is the catalytic subunit of γ-secretase, the enzyme responsible for the Aβ C-terminal cleavage site, which results in the production of Aβ peptides of various lengths. Production of longer forms of the Aβ peptide occur in patients with autosomal dominant Alzheimer disea...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Uemura, Kengo, Lill, Christina M., Li, Xuejing, Peters, Jessica A., Ivanov, Alexander, Fan, Zhanyun, DeStrooper, Bart, Bacskai, Brian J., Hyman, Bradley T., Berezovska, Oksana
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2009
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773935/
https://ncbi.nlm.nih.gov/pubmed/19924286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007893
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla