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Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation
BACKGROUND: Several familial Alzheimer disease (FAD) mutations within the transmembrane region of the amyloid precursor protein (APP) increase the Aβ(42/40 )ratio without increasing total Aβ production. In the present study, we analyzed the impact of FAD mutations and γ-secretase modulators (GSMs) t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3046905/ https://ncbi.nlm.nih.gov/pubmed/21310068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-15 |
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