Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

BACKGROUND: Several familial Alzheimer disease (FAD) mutations within the transmembrane region of the amyloid precursor protein (APP) increase the Aβ(42/40 )ratio without increasing total Aβ production. In the present study, we analyzed the impact of FAD mutations and γ-secretase modulators (GSMs) t...

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Détails bibliographiques
Auteurs principaux: Uemura, Kengo, Farner, Katherine C, Nasser-Ghodsi, Navine, Jones, Phill, Berezovska, Oksana
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3046905/
https://ncbi.nlm.nih.gov/pubmed/21310068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-15
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