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Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer’s Disease Mouse Model
Dendritic spines, the site of most excitatory synapses in the brain, are lost in Alzheimer’s disease and in related mouse models, undoubtedly contributing to cognitive dysfunction. We hypothesized that spine loss results from plaque-associated alterations of spine stability, causing an imbalance in...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Investigative Pathology
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1988879/ https://ncbi.nlm.nih.gov/pubmed/17717139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070055 |
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