Impaired Spine Stability Underlies Plaque-Related Spine Loss in an Alzheimer’s Disease Mouse Model

Dendritic spines, the site of most excitatory synapses in the brain, are lost in Alzheimer’s disease and in related mouse models, undoubtedly contributing to cognitive dysfunction. We hypothesized that spine loss results from plaque-associated alterations of spine stability, causing an imbalance in...

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Bibliografski detalji
Glavni autori: Spires-Jones, Tara L., Meyer-Luehmann, Melanie, Osetek, Jennifer D., Jones, Phillip B., Stern, Edward A., Bacskai, Brian J., Hyman, Bradley T.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2007
Teme:
Regular Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988879/
https://ncbi.nlm.nih.gov/pubmed/17717139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.070055
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