Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

APOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1(–/–) mice have decreased lipid associated with apoE and increased amyloid deposition in several AD mouse mod...

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Hauptverfasser: Wahrle, Suzanne E., Jiang, Hong, Parsadanian, Maia, Kim, Jungsu, Li, Aimin, Knoten, Amanda, Jain, Sanjay, Hirsch-Reinshagen, Veronica, Wellington, Cheryl L., Bales, Kelly R., Paul, Steven M., Holtzman, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200302/
https://ncbi.nlm.nih.gov/pubmed/18202749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33622
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